{"product_id":"immunological-investigation-of-autoimmune-bullous-dermatoses-von-ameni-jerbi","title":"Immunological investigation of autoimmune bullous dermatoses","description":"\u003cp\u003eAutoimmune bullous dermatoses (ABD) are specific autoimmune diseases of the skin and mucous membranes. They are characterized by the presence of autoantibodies (auto-Ab) directed against skin and mucous membrane adhesion molecules, leading to altered function of their antigenic targets, resulting in clinical bullae and\/or erosions. Depending on the site of cleavage, a distinction is made between intra-epidermal DBAI, characterized by auto-Ac directed against the structural proteins of the desmosomes that hold the keratinocytes of the epidermis together; and sub-epidermal DBAI, characterized by the presence of auto-Ac directed against the components of the dermo-epidermal junction (DEJ).The diagnosis of DBAI is based on clinical, histopathological and immunological evidence (detection of circulating or tissue-deposited auto-Ac). Direct immunofluorescence (DIF) is an immunological technique performed on cryosections of peri-lesional biopsies, based on the detection of Ac deposits and\/or complement fractions using specific fluorescein-conjugated Ac.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786208187873\"\u003e\u003ch3\u003eInterest of direct immunofluorescence on skin biopsy in the exploration of autoimmune bullous dermatoses\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786208187873","offer_id":55864001790277,"sku":"9786208187873","price":43.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/cdbfd72d-01c4-48db-ba19-9f942757dd92.jpg?v=1777353716","url":"https:\/\/shop.autorenwelt.de\/products\/immunological-investigation-of-autoimmune-bullous-dermatoses-von-ameni-jerbi","provider":"Autorenwelt Shop","version":"1.0","type":"link"}