{"product_id":"immune-response-to-hib-conjugate-vaccine-in-infants-von-ediamu-tom-didimus","title":"Immune Response to Hib Conjugate Vaccine in infants","description":"\u003cp\u003eInvasive disease due to Haemophilus influenzae typeb (Hib) is common in both HIV infected and un-infected children and immunisation with Hib conjugate vaccines is recommended. However, a few studies done showed that HIV infection blunts antibody response to childhood vaccines.  The main objective of this study was to assess the ability of both HIV infected and un-infected Ugandan infants seen at Mulago hospital to mount protective antibody responses and highlight some of the factors that affect response. 159 infants were recruited; 8 were lost to follow up. Of the 151 analyzed, 53 were HIV infected and 98 un-infected. The serum antibody responses were determined by ELISA just before the 3rd dose and a minimum of one month after the dose.  81.6% of the HIV un-infected and 56.6% of the HIV infected achieved protective antibodies after the 3rd dose. 3 doses were better than 2 for both groups. Independent predictors for inadequate antibody response were HIV infection and splenomegally in an HIV infected infant Vitamin A had a potentiating effect on response in infants above 6 months.  The study results formed a basis for evaluating the efficacy of the Hib conjugate vaccine in the country.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659112225\"\u003e\u003ch3\u003eComparison of response among HIV infected and un-infected infants attending Mulago Hospital Kampala\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783659112225","offer_id":39489809449053,"sku":"9783659112225","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/35a15114-24e4-4f7a-a28f-2c304da86ffe.jpg?v=1774678570","url":"https:\/\/shop.autorenwelt.de\/products\/immune-response-to-hib-conjugate-vaccine-in-infants-von-ediamu-tom-didimus","provider":"Autorenwelt Shop","version":"1.0","type":"link"}