{"product_id":"imatinib-plasma-concentrations-variability-in-oncologic-patients-von-nicolas-widmer","title":"Imatinib plasma concentrations variability in oncologic patients","description":"\u003cp\u003eThe anticancer drug imatinib has transformed the  treatment and prognosis of chronic myeloid leukemia  and gastrointestinal stromal tumor. However, the  treatment must be taken indefinitely and is not  devoid of inconveniences and toxicity. Moreover,  resistance or escape from disease control are  occurring. Considering the large interindividual  differences in the function of the enzymatic and  transport systems involved in imatinib disposition,  exposure to this drug can be expected to vary widely  among patients. This book describes an observational  clinical trial aiming at exploring the influence of  these covariates on imatinib pharmacokinetics and  assessing the interindividual variability of the  pharmacokinetic parameters of the drug. A large  interindividual variability was observed, together  with some preliminary concentration-effect  relationships. These elements are arguments to  further investigate the potential benefit of a  therapeutic drug monitoring program to optimize the  use of imatinib in patients. Such results should be  especially useful to clinical oncologists or  scientists involved in clinical oncology research.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838385112\"\u003e\u003ch3\u003eIs imatinib a candidate drug for a therapeutic drug monitoring program?\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838385112","offer_id":39499035279453,"sku":"9783838385112","price":79.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/6b7379c2-57eb-4539-8216-14a5e8e9c370.jpg?v=1768891766","url":"https:\/\/shop.autorenwelt.de\/products\/imatinib-plasma-concentrations-variability-in-oncologic-patients-von-nicolas-widmer","provider":"Autorenwelt Shop","version":"1.0","type":"link"}