{"product_id":"identifying-genes-that-encode-app-metabolism-modulators-von-can-zhang","title":"Identifying Genes That Encode APP Metabolism Modulators","description":"\u003cp\u003eAlzheimer''s disease (AD) is a devastating neurodegenerative disease with complex and strong genetic inheritance. The central pathological event in AD is believed to be the regulated intramembrane proteolysis of the amyloid-beta precursor protein (APP), which generates accumulable amyloid-beta peptide and the APP intracellular domain (AICD). The genetic cause of AD is not fully identified, and up to 70% of the heritability of AD is unknown. In this \"translational\" study, we hijacked the transcriptional activation property of the AICD fragment and constructed a functional assay to discover novel APP metabolism regulators. We have identified 11 positional candidate genes in an AD risk linkage region on chromosome 9 where the AD candidate gene, ubiquilin 1 (UBQLN1), has been previously found. Our data also showed that UBQLN1, which encodes a protein involved in protein degradation and quality control, modulates APP metabolism through a cell type-dependent mechanism. Collectively, we report a novel approach in functional genomics that provides a robust tool to identify novel AD candidate genes and may serve to provide insight into the pathogenesis of AD.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838360898\"\u003e\u003ch3\u003eA novel approach in functional genomics to gain insight into the pathogenesis of Alzheimer's disease\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838360898","offer_id":39469197525085,"sku":"9783838360898","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/4b76a2c1-b3f8-458b-87f2-db76b1e6e6d2.jpg?v=1737181986","url":"https:\/\/shop.autorenwelt.de\/products\/identifying-genes-that-encode-app-metabolism-modulators-von-can-zhang","provider":"Autorenwelt Shop","version":"1.0","type":"link"}