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Hydrogel For Oral Mucositis: Formulation and in-vivo characterization of hydrogel for treatment of Chemo-radiotherapy induced oral mucositis

Hydrogel For Oral Mucositis: Formulation and in-vivo characterization of hydrogel for treatment of Chemo-radiotherapy induced oral mucositis

von M. L. Kori, Praveen Kumar Jain
Taschenbuch - 9783639514056
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Beschreibung

As mucositis represents a significant clinical, and importantly, economic burden in oncology and stem cell or bone marrow transplantation. The aim of this study is to develop mucoadhesive system that can deliver the drug in the buccal cavity in effective concentration for prophylaxis and or treatment of oral mucositis. For this purpose hydrogel of L-glutamine with different polymer is prepared. It is crucial that the carrier gel matrix preserve physical and mechanical integrity. Mechanical stability of the gel is, therefore, a significant consideration when scheming a therapeutic system. The main benefit of hydrogel formulation is that it hold dose, which is adequate for therapeutic effect as it is positioned directly on the site of mucositis. Moreover this hydrogel is very tolerable and comfy because it is non-irritant and may be chosen over other adhesive dosage form in terms of flexibility, capability and protective to wounded or inflamed surfaces.

Details

Verlag SPS
Ersterscheinung Oktober 2013
Maße 220 mm x 150 mm x 8 mm
Gewicht 225 Gramm
Format Taschenbuch
ISBN-13 9783639514056
Auflage Nicht bekannt
Seiten 140

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