Hormonal Carcinogenesis III: Proceedings of the Third International Symposium

Hormonal Carcinogenesis III: Proceedings of the Third International Symposium

Taschenbuch - 9781461274117
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Beschreibung

Since our previous symposium in 1995, the pace of research in hormones and cancer has accelerated. Progress in our understanding of hormonal carcinogenic processes has been a direct result of the advances made in cell biology, endocrinology, and carcinogenesis at the molecular level. The newer fields of molecular genetics and cytogenetics already have and are expected to continue to playa major role in furthering our understanding of the cellular and molecular events in hormonal carcinogenesis. It has become increasingly clear that the risk of naturally occurring sex hormones in carcinogenic processes, both in human and in animal models, requires only minute quantities of hormones, at both the serum and tissue levels. Moreover, hormone target tissues for neoplastic transformation, perhaps with the exception of the liver, generally have relatively modest ability to metabolize sex hormones, such as the breast and prostate. Table 1 summarizes the serum, and in most cases, the tissue levels of sex hormones, both endogenously and exogenously ingested, which are associated with increased risk for endocrine-associated cancers such as breast, endometrium, and prostate, as well as the hormone levels of four experimental models that have been shown to elicit high tumor incidences. In contrast to the human, in which the hormone levels are cyclic, however, the latter require continuous hormone exposure at these relatively low levels.

Details

Verlag Springer New York
Ersterscheinung Oktober 2011
Maße 235 mm x 155 mm x 32 mm
Gewicht 900 Gramm
Format Taschenbuch
ISBN-13 9781461274117
Auflage Softcover reprint of the original 1st ed. 2001
Seiten 604

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