{"product_id":"hiv-genetics-evaluation-and-viral-dynamics-von-dhairya-y-joshi-bhuvan-p-raval-und-ashok-l-ganure","title":"HIV Genetics Evaluation And Viral Dynamics","description":"\u003cp\u003eThere are the two type of HIV mainly they are HIV-1 and HIV-2. HIV-2 is less pathogenic and less transmissible compared to HIV-1. This is believed to be due to the lower viral load that is seen in HIV-2 infected patients.  genetic variation and evolution in the pol gene was studied, with special interests in resistance-associated mutations in HIV-2 infected patients failing antiretroviral treatment. There is observation in some mutations known to cause resistance in HIV-1 such as M184V, Q151M and E219D; but most resistance mutations appeared to differ from what is known in HIV-1. The main conclusion from this work is that specific algorithms for HIV-2 resistance interpretation are needed, because the algorithms for HIV-1 cannot be used. They were studied the evolution of co-receptor usage, neutralization escape and env gene sequence. It is reported that a switch from CCR5 to CXCR4 using virus during disease progression. They did not see a clear pattern of neutralization escape as is seen in HIV-1. A pattern of changes in the number of potential N-linked glycosylation sites during disease progression has been observed. HIV-2 has fewer potential N-linked glycosylation sites in V3.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783846555415\"\u003e\u003ch3\u003eExploring HIV\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783846555415","offer_id":39494553403485,"sku":"9783846555415","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/e8bbed58-3f67-476c-9efe-b7fbfe85733f.jpg?v=1759296659","url":"https:\/\/shop.autorenwelt.de\/products\/hiv-genetics-evaluation-and-viral-dynamics-von-dhairya-y-joshi-bhuvan-p-raval-und-ashok-l-ganure","provider":"Autorenwelt Shop","version":"1.0","type":"link"}