{"product_id":"heterocycles-in-organic-synthesis-their-synthesis-and-applications-von-reham-f-barghash","title":"Heterocycles in Organic Synthesis: Their Synthesis and Applications","description":"\u003cp\u003eBased on the recorded pharmacological potencies of numerous substituted pyrimidines as antihyperlipemic and antihypertensive agents, synthesis of condensed and spiro bis-heterocyclic systems; oxazole-pyrimidines as well as pyrimido-oxazines; bearing a phosphonate substituent was undertaken. The bioassay indicated that some of the products have effect on the central nervous system (CNS), and other products have good selective anti-tumor activity and the structure-activity relationship (SAR) of new phosphonates has also been indicated. In addition, a new class of C-glycosyl amino acids bearing a thiourea segment as a linker has been designed and synthesized by addition of glycosylmethyl isothiocyanates to an amine-functionalized amino acid. The orthogonal set of protective groups makes these compounds suitable substrates for the co-translational modification of natural peptides. The study included the synthesis of a set of new sugar isothiocyanates and their coupling with the alanine derivative.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783843378444\"\u003e\u003ch3\u003eSynthesis of Novel Heterocycles and Unnatural Glycosyl Amino Acids with their Biochemical and Pharmaceutical Studies and Applications\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783843378444","offer_id":39497054355549,"sku":"9783843378444","price":79.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/c88aed68-cc3b-4329-a1a8-bff1a1989cb5.jpg?v=1757655668","url":"https:\/\/shop.autorenwelt.de\/products\/heterocycles-in-organic-synthesis-their-synthesis-and-applications-von-reham-f-barghash","provider":"Autorenwelt Shop","version":"1.0","type":"link"}