{"product_id":"haem-oxygenase-1-protects-pulmonary-vascular-function-von-hany-el-bassossy","title":"HAEM OXYGENASE-1 PROTECTS PULMONARY VASCULAR FUNCTION","description":"\u003cp\u003eDisturbances in pulmonary vascular reactivity are  important early components of inflammatory lung  disease. The present study aims to extrapolate the  relationship between the inflammatory response and  changes in pulmonary vascular response and to  investigate the potential protective effect of HO-1  against inflammation-induced disturbance in  pulmonary vascular response. A number of techniques  were used to achieve these goals including: the  isolated artery technique, real time recording,  confocal fluorescence microscopy, HO 1  immunoblotting, immunofluorescence techniques, HO  activity assay and flow cytometry. We have shown,  for the first time, that induction of HO-1 protein  and activity was associated with protection against  cytokine induced dysfunction of pulmonary artery  relaxation and that this protection was mediated by  modulation of NO production in arterial tissue.  These findings suggest upregulation of HO-1 as a  novel potential therapy in the management of  vascular disturbances associated with inflammatory  lung disease.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783843381284\"\u003e\u003ch3\u003eHAEM OXYGENASE-1: A PROTECTIVE GENE AGAINST INFLAMMATION-INDUCED IMPAIRMENT IN PULMONARY VASCULAR FUNCTIONS\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783843381284","offer_id":39470008467549,"sku":"9783843381284","price":79.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/02cbec3b-bc6d-43a8-bf84-07d3c1106904.jpg?v=1768976454","url":"https:\/\/shop.autorenwelt.de\/products\/haem-oxygenase-1-protects-pulmonary-vascular-function-von-hany-el-bassossy","provider":"Autorenwelt Shop","version":"1.0","type":"link"}