{"product_id":"glucocorticoid-receptor-based-transrepressive-mechanisms-von-ilse-beck","title":"Glucocorticoid receptor-based transrepressive mechanisms","description":"\u003cp\u003eInflammation is one of the biggest challenges in current medicine. Glucocorticoid-based therapy is still the most commonly used treatment to combat chronic and acute inflammation. However, as this treatment is burdened with a detrimental side effect profile and the occurrence of glucocorticoid resistance, research efforts are focused on characterizing the anti-inflammatory mechanisms of glucocorticoids and developing new therapeutic strategies to fight inflammation.  In this book, focus is put on the effects of the glucocorticoid receptor on NF-kB and NF-¿B-driven gene expression. The transcription factor NF-¿B is namely key to the onset and propagation of inflammation. Special attention is also given to the effects of glucocorticoids on the kinase MSK1 and the associated chromatin and NF-¿B modulations. In a second chapter, we explore alternative glucocorticoid receptor function via the selective agonist Compound A. Further unravelling the underlying mechanism of how glucocorticoids mediate anti-inflammatory gene repression is a very important issue for molecular researchers, biochemists, medical doctors and specialists, pharmaceutical companies, and product managers.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838339887\"\u003e\u003ch3\u003eAt promoters of inflammatory genes\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838339887","offer_id":39498962534493,"sku":"9783838339887","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/8dad03d5-b92e-4563-958a-d3d5016203bb.jpg?v=1757656977","url":"https:\/\/shop.autorenwelt.de\/products\/glucocorticoid-receptor-based-transrepressive-mechanisms-von-ilse-beck","provider":"Autorenwelt Shop","version":"1.0","type":"link"}