{"product_id":"glial-cells-in-the-enteric-nervous-system-plasticity-of-glial-cells-in-the-enteric-nervous-system-during-intestinal-inflammation-von-sebastian-hoff","title":"Glial cells in the enteric nervous system","description":"\u003cp\u003eEnteric glial cell (EGC) markers were thoroughly characterized in the human enteric nervous system (ENS) and EGC numbers were compared in man and guinea pig. As a result, the Sox8\/9\/10 antibody was shown to be an excellent investigative tool to assess EGC in the ENS and the glia index was identified as the most robust quantitative descriptor within a species. Subsequently, this Sox8\/9\/10 was used in Crohn¿s disease specimens to quantify enteric glia. In a parallel approach, interactions of EGC and the intestinal epithelial barrier were analyzed. Results from these experiments indicate a protective effect of EGCs on the intestinal epithelial barrier in intestinal inflammation. The observed expression of GDNF, NGF, NT-3 and their receptors by EGC points to promising targets for further research to elucidate the exact nature of glial-derived mucosa-protective factors.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838107257\"\u003e\u003ch3\u003ePlasticity of glial cells in the enteric nervous system during intestinal inflammation\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783838107257","offer_id":39435322949725,"sku":"9783838107257","price":69.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/d6eaab43-d3ea-4c19-8abe-0c429bec2768.jpg?v=1773213214","url":"https:\/\/shop.autorenwelt.de\/products\/glial-cells-in-the-enteric-nervous-system-plasticity-of-glial-cells-in-the-enteric-nervous-system-during-intestinal-inflammation-von-sebastian-hoff","provider":"Autorenwelt Shop","version":"1.0","type":"link"}