{"product_id":"genetic-susceptibility-to-coxsackievirus-b3-myocarditis-von-mahmoud-aly","title":"GENETIC SUSCEPTIBILITY TO COXSACKIEVIRUS B3 MYOCARDITIS","description":"\u003cp\u003eCoxsackievirus B3 (CVB3) is the second main causes  of viral myocarditis. Mouse infection with CVB3  mimics the heterotypic response to virus-induced  disease observed in humans. Here we have used Evans  blue dye as a quantitative biomarker for  susceptibility to CVB3-induced myocarditis in  addition to histopathological semi quantitative  measures. We have found evidence of linkage between  susceptibility to viral myocarditis and three loci.  A locus on chromosome 1 was linked to sarcolemmal  disruption in males (P=0.00005), a second locus on  chromosome 4 was also linked to sarcolemmal  disruption in males (P=0.0022). A third locus on  distal chromosome 3  was linked  to myocardial infiltration, with a logarithm of odds  (LOD) score of 4.7 (P=0.0045), as well as  sarcolemmal disruption in females (P=0.0015).  These results provide strong evidence for the  presence of loci contributing to the susceptibility  of mice to viral myocarditis. Given the complexity  of the regulation, development and prognosis of  myocarditis the  QTLs identified in this study will  represent new avenues for developing new therapeutic  strategies to control the disease.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783844300260\"\u003e\u003ch3\u003eCOMPLEX GENETIC CONTROL OF THE SUSCEPTIBILITY TO VIRAL MYOCARDITIS IN THE MOUSE MODEL\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783844300260","offer_id":39470059520093,"sku":"9783844300260","price":79.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/3b5997f9-d1b7-4ae7-ad5b-36ee59ace2a8.jpg?v=1757656968","url":"https:\/\/shop.autorenwelt.de\/products\/genetic-susceptibility-to-coxsackievirus-b3-myocarditis-von-mahmoud-aly","provider":"Autorenwelt Shop","version":"1.0","type":"link"}