{"product_id":"gastrointestinal-stromal-tumors-von-sarra-ben-rejeb-und-dorra-aloui","title":"GASTROINTESTINAL STROMAL TUMORS","description":"\u003cp\u003eThe molecular alterations most frequently associated with GIST are mutations in the KIT and PDGFRA genes. Many other genetic abnormalities have been described, such as amplification of C-MYC, MDM2, EGFR1 and CCND1. The objective of this study was to analyze by immunohistochemical method the prognostic value of C-MYC and EGFR overexpression in GIST. We retrospectively collected 25 cases of GIST diagnosed in our department over a period of 15 years (2008-2023). The expression of EGFR and C-MYC was carried out by immunohistochemical method. C-MYC immunostaining was categorized into low and high expression levels with a threshold of 25%. The intensity of immunostaining and the percentage of EGFR-positive cells were evaluated and grouped according to the Allred score parameters. Only cases with an EGFR TS score \u0026gt;4 were considered overexpressed. We included 25 cases. The average age of patients was 60 years with a male-to-female ratio of 1.5. C-MYC expression was observed in 60% of cases, with elevated levels in 33% of cases.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786207145515\"\u003e\u003ch3\u003ePROGNOSTIC BIOMARKERS\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786207145515","offer_id":47628853150021,"sku":"9786207145515","price":60.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/d2b46165-4058-4df3-910a-a53cd409c782.jpg?v=1749445458","url":"https:\/\/shop.autorenwelt.de\/products\/gastrointestinal-stromal-tumors-von-sarra-ben-rejeb-und-dorra-aloui","provider":"Autorenwelt Shop","version":"1.0","type":"link"}