{"product_id":"galectin-1-and-apoptosis-von-ehab-aboueladab","title":"Galectin-1 and apoptosis","description":"\u003cp\u003eGalectin-1 (gal-1), a member of the family of beta  galactoside binding proteins, participates in  several biological processes such as  immunomodulation, cell adhesion, regulation of cell  growth and apoptosis. The aim of this study was to  investigate whether gal-1 the mechanisms of T cell  activation on the level of signal transduction  induced by galectin-1 (gal-1) having  immunosuppressive activity. Gal-1 recognizes and  cross-links appropriate glycoepitopes (Gal¿1- 4GlcNAc- sequences) on T cell activation markers (CD2, CD3,  CD45) and stimulates in parallel several  interacting  signalling pathways leading to suppression of the  expression of Th1 cytokines and to apoptosis in  thymocytes, activated T- cells, and in leukemic T  cell lines. In cellular models by applying cell-  and  glycobiological methods we have focused on gal-1  induced or suppressed signalling pathways involved  in inhibition of a processive immune response of  antigen-stimulated T lymphocytes. In this way, by  depletion of activated T cells gal-1 is a negative  regulator of the immune response. Therefore, the  mechanism of gal-1 induced T cell apoptosis is of  special interest.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838334837\"\u003e\u003ch3\u003eInduction of apoptosis in galectin-1 stimulated Jurkat T lymphocytes\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838334837","offer_id":39498900013149,"sku":"9783838334837","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/b4fbc170-16a3-4ddf-8a2c-42ae5db270b5.jpg?v=1758348212","url":"https:\/\/shop.autorenwelt.de\/products\/galectin-1-and-apoptosis-von-ehab-aboueladab","provider":"Autorenwelt Shop","version":"1.0","type":"link"}