{"product_id":"formulation-and-evaluation-of-sustained-release-tablets-of-tizanidine-von-venkata-raghava-reddy-p-rayala-venkatakoteswararao","title":"Formulation and Evaluation of Sustained release tablets of Tizanidine","description":"\u003cp\u003eThe objective of this study is to formulate and evaluate the sustained release matrix tablet of Tizanidine Hydrochloride by direct compression method. In the present study, Tizanidine is chosen as a model drug which is Muscle relaxant. Because of its short half life (2.5hrs), its water solubility and less bioavailability (40%) it was chosen as a suitable candidate for sustain matrix tablet formulation. It was formulated in to matrix tablet using polymer such as iota-Carrageenan and Polyethylene oxide as releases retardants. All the pre-compression parameters, post-compression parameters were found to be within the standard IP limits. Matrix tablet with Carrageenan and Polyethylene oxide successfully sustained the release of Tizanidine for a period of 12hrs. The concentration of tizanidine was kept constant, MCC-101 and lactose (1:3 ratio) used as filler. The maximum in-vitro release (at 50rpm, temperature 37±0.5°C, and 0.1N HCl, pH 6.8 phosphate buffers) was found to be 97.8% and 98.6% over a period of 12hrs for formulations C4 and P4. The data of in-vitro release from tablets were fitted to different kinetic models to explain the release profile. Formulations C4 and P4 were best\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783330051560\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783330051560","offer_id":39420865314909,"sku":"9783330051560","price":49.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/3493ddee-4636-4626-816e-45947d80d9e8.jpg?v=1769491155","url":"https:\/\/shop.autorenwelt.de\/products\/formulation-and-evaluation-of-sustained-release-tablets-of-tizanidine-von-venkata-raghava-reddy-p-rayala-venkatakoteswararao","provider":"Autorenwelt Shop","version":"1.0","type":"link"}