{"product_id":"formulation-and-development-of-bilayer-floating-tablets-of-nifedipine-formulation-and-development-of-bilayer-floating-tablets-of-nifedipine-using-surface-solid-dispersion-technique-von-dinesh-kumar-sharma-amulyaratna-behera-gurudutta-pattnaik","title":"Formulation and Development of Bilayer Floating Tablets of Nifedipine","description":"\u003cp\u003eThe aim of the present research work was to develop and formulate a bilayer floating sustained release tablet of Nifedipine. Nifedipine is an antihypertensive agent. Surface solid dispersion of Nifedipine was prepared by solvent evaporation method with different super disintegrants as a polymer for improvement of solubility resulting in improved bioavailability. Bilayer consists of two layers, immediate-release layer, and second sustained release layer, compressed in the single unit dosage form. The immediate-release layer contains surface solid dispersion of Nifedipine. The floating sustained release layer also contains surface solid dispersion of Nifedipine, HPMC K100M \u0026amp; HPMC K15M as sustained release polymer. The floating properties of the tablets were achieved by the use of sodium bicarbonate \u0026amp; citric acid which generate the gas upon contact with gastric fluid. The immediate-release layer releases the drug immediately and starts the onset of action and the floating sustained release layer floats on gastric fluid for upto12 hours and releases the drug in a sustained manner, subsequently, it prolongs the duration of action.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786203410877\"\u003e\u003ch3\u003eFormulation and Development of Bilayer Floating Tablets of Nifedipine Using Surface Solid Dispersion Technique\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9786203410877","offer_id":39465961783389,"sku":"9786203410877","price":54.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/bea6f940-161a-4e4b-afcb-e641e53a6fe2.jpg?v=1769495966","url":"https:\/\/shop.autorenwelt.de\/products\/formulation-and-development-of-bilayer-floating-tablets-of-nifedipine-formulation-and-development-of-bilayer-floating-tablets-of-nifedipine-using-surface-solid-dispersion-technique-von-dinesh-kumar-sharma-amulyaratna-behera-gurudutta-pattnaik","provider":"Autorenwelt Shop","version":"1.0","type":"link"}