{"product_id":"formation-and-cooperative-behaviour-of-protein-complexes-on-the-cell-membrane-von-ksenia-guseva","title":"Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane","description":"\n                \u003cp\u003eWith the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this self-organizing process.\u003c\/p\u003e\n            \u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783642269943\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783642239878\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783642269943","offer_id":39430503465053,"sku":"9783642269943","price":53.49,"currency_code":"EUR","in_stock":true},{"title":"Hardcover - 9783642239878","offer_id":47105486913861,"sku":"9783642239878","price":53.49,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/59a0beb1-8de9-47a8-9dc4-856d01fe807c.jpg?v=1775280760","url":"https:\/\/shop.autorenwelt.de\/products\/formation-and-cooperative-behaviour-of-protein-complexes-on-the-cell-membrane-von-ksenia-guseva","provider":"Autorenwelt Shop","version":"1.0","type":"link"}