{"product_id":"first-trimester-fetal-diagnosis-von-bruno-brambati-marco-fraccaro-giuseppe-simoni-hrsg","title":"First Trimester Fetal Diagnosis","description":"\u003cp\u003eOf 646 cases involving first trimester chromosome analysis of chorionic villi sam­ ples obtained by trans cervical aspiration, we found 34 abnormal unbalanced karyo­ types. In six of these, fetal fibroblast cultures obtained after termination of the preg­ nancy failed to confirm the abnormality. Three cases were mosaics identified from direct preparations: 46,XY\/45,X; 46,XX\/47,XX,+3; and 46,XY\/47,XY,+18. In two cases of trisomy 16 (46,XY\/47,XY,+16; 46,XX\/47,XX,+16) and one oftriso­ my18 (46,XX\/47,XX,+18), no mosaicism was detected. In the other 28 cases with unbalanced abnormal karyotypes, there was karyotypic correspondence between villous cells at diagnosis and fetal fibroblasts. References 1. Benn P, Hsu L YF, Perlis T, Schonhaut A (1984): Prenatal diagnosis of chromosome mosaicism. Prenat Diagn 4: 1-9 2. Binkert F, Schmid W (1977) Pre-implantation embryos of Chinese hamster. I. Incidence ofkaryo­ type anomalies in 226 control embryos. Mutat Res 46: 63-76 3. Boue J, Nicolas H, Barichard F, Boue A (1979) Le clonage des cellules du liquide amniotique, aide dans l'interpretation des mosaiques chromosomiques en diagnostic prenatal. Ann Genet 22:3-9 4. Hahnemann N (1973) Chromosome studies in induced abortions. Clin Genet 4: 328-332 5. Kalousek DK, Dill FJ (1983) Chromosomal mosaicism confined to the placenta in human con­ ceptions. Science 221 : 665-667 6. Loft A, Tabor A (1984) Discordance between prenatal cytogenetic diagnosis and outcome of pregnancy. Prenat Diagn 4: 51-59 7. Markert CL, Petters RM (1978) Manufactured hexaparental mice show that adults are derived from three embryonic cells.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783540157854\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783540157854","offer_id":39425973321821,"sku":"9783540157854","price":106.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/cf6b68b9-0687-4eee-8b01-576dffa175ec.jpg?v=1761803901","url":"https:\/\/shop.autorenwelt.de\/products\/first-trimester-fetal-diagnosis-von-bruno-brambati-marco-fraccaro-giuseppe-simoni-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}