{"product_id":"feedback-model-of-extracellular-dopamine-concentration-control-von-elena-koshkina","title":"Feedback model of extracellular dopamine concentration control","description":"\u003cp\u003eDopamine is one of the central neurotransmitters;   its  homeostatic concentration is maintained through  release, uptake, and feedback. The extracellular  dopamine concentration is regulated presynaptically  by the dopamine transporter (DAT) and dopamine  autoreceptors. The postsynaptic control is mediated  by postsynaptic dopamine receptors. Dopamine is the  subject of a numerous experimental studies. As a  result, great deal of experimental data describing  the components of dopamine system has been   collected.  This experimental data provides an excellent  foundation for theoretical study to model complex  dopamine system. Mathematical modeling was based on  published pharmacokinetic parameters for dopamine  uptake and receptor binding in rat striatum.  It was  demonstrated computationally that both uptake by DAT  and negative feedback mediated by receptors are  necessary components to maintain a low extracellular  dopamine concentration under basal conditions. The  mathematical modeling also showed the critical role  of negative feedback to control stable extracellular  dopamine concentration under conditions of  increased\/decreased dopamine release.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838354354\"\u003e\u003ch3\u003eExtracellular dopamine concentration control: computational model of feedback control\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838354354","offer_id":39471304212573,"sku":"9783838354354","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/75e11cb6-d2f0-470a-b73f-ab8b42f18ce4.jpg?v=1758260756","url":"https:\/\/shop.autorenwelt.de\/products\/feedback-model-of-extracellular-dopamine-concentration-control-von-elena-koshkina","provider":"Autorenwelt Shop","version":"1.0","type":"link"}