{"product_id":"farmakogenetika-ostrogo-limfoblasticheskogo-lejkoza-von-rim-frikha","title":"Farmakogenetika ostrogo limfoblasticheskogo lejkoza","description":"\u003cp\u003eNashi issledowaniq byli sosredotocheny na izuchenii uchastiq polimorfizmow (S677T i A1298S) gena MTHFR w farmakogenetike ostrogo limfoblasticheskogo lejkoza (OLL), w chastnosti, pri wysokodozirowannom metotrexate (MTX-HD). Nesmotrq na dokazannuü klinicheskuü äffektiwnost', poslednqq mozhet wyzwat' tqzheluü toxichnost'. Byl sobran 41 mladshij rebenok, za kotorym posledowali VSE. Genotipirowanie ätih dwuh wariantow korrelirowalo s terapewticheskim otwetom i farmakologicheskimi analizami (MTH i gomocistein).V to wremq kak MTHFR C677T qwlqetsq horoshim markerom toxichnosti MTX-HD, A1298C - net. Tem ne menee, net korrelqcii mezhdu wariantom C677T i farmakokineticheskimi parametrami pri primenenii MTX-HDV zaklüchenie, nesmotrq na debaty o suschestwowanii farmakogeneticheskogo markera dlq ispol'zowaniq MTH w klinicheskoj praktike, C677T polimorfizm MTHFR pokazywaet mnogoobeschaüschie rezul'taty.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786203539189\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786203539189","offer_id":40150509322333,"sku":"9786203539189","price":39.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/f2557ccf-fadc-42dd-b955-52a3621fa258.jpg?v=1757484583","url":"https:\/\/shop.autorenwelt.de\/products\/farmakogenetika-ostrogo-limfoblasticheskogo-lejkoza-von-rim-frikha","provider":"Autorenwelt Shop","version":"1.0","type":"link"}