{"product_id":"fanconi-anemia-clinical-cytogenetic-and-experimental-aspects-von-arleen-d-auerbach-gunter-obe-traute-m-schroeder-kurth-hrsg","title":"Fanconi Anemia","description":"\u003cp\u003eSixty years ago, G. Fanconi published a paper entitled: \"Familiiire infantile pemiziosaartige Aniimie (pemizioses Blutbild und Konstitu­ tion)\", in which he reported that this type of severe aplastic anemia represents a hereditary disease distinct from other pancytopenias of childhood (Fanconi 1927). Later this syndrome was named Fan­ coni anemia (FA; van Leeuwen 1933). A more recent study of the genetics of FA confirmed that the syndrome is inherited in an au­ tosomal recessive manner (Schroeder et al. 1976). Prenatal diagno­ sis in FA families showed that about 25% of fetuses are affected (Auerbach et al. 1985, 1986). In 1964, Schroeder et al. discovered high frequencies of chro­ mosomal aberrations in cultured peripheral blood lymphocytes from patients with FA. Schuler et al. (1969) reported that cells from FA patients are particularly sensitive to the chromosome-breaking activity or clastogenic effect of a polyfunctional alkylating agent. Since that time, studies of baseline and induced frequencies of chromosomal aberrations have been used for the identification of patients with FA. There is now a large body of data concerning the possible mechanism(s) underlying the hypersensitivity of FA cells to DNA cross-linking agents, the biochemical basis for which is still unknown. Complementation analysis, using cells from different FA pa­ tients, has demonstrated genetic heterogeneity in the syndrome.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783642741814\"\u003e\u003ch3\u003eClinical, Cytogenetic and Experimental Aspects\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783642741814","offer_id":39444490780765,"sku":"9783642741814","price":106.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/010ca75a-38ab-4b73-a406-c17f51fa029f.jpg?v=1755665302","url":"https:\/\/shop.autorenwelt.de\/products\/fanconi-anemia-clinical-cytogenetic-and-experimental-aspects-von-arleen-d-auerbach-gunter-obe-traute-m-schroeder-kurth-hrsg","provider":"Autorenwelt Shop","version":"1.0","type":"link"}