{"product_id":"expression-of-th17-related-cytokines-il17a-and-f-in-severe-asthma-von-wisam-al-ramli","title":"Expression of Th17 related cytokines IL17A and F in severe asthma","description":"\u003cp\u003eSevere asthma represents a distinct, poorly-understood phenotype of asthma that has higher morbidity, mortality and a disproportionate need for health care support. Studies have indicated the presence of a specific inflammatory response in severe asthmatics, including the paucity of expression of classical Th-2 type cytokines. Following antigenic stimulation, naive CD4+ T cells proliferate and differentiate into various effector subsets such as Th-1 and Th-2 cells. A third subset of CD4+ T cells has recently been identified and designated as Th-17 cells, which produce IL-17A and F, IL-6, and TNF-alpha. In severe asthma, there may be a predominant Th-17 phenotype. These cells may promote the release of neutrophil chemotactic factors and induce the expression of GR-beta, which is responsible for corticosteroid hyporesponsiveness in immune and structural cells. If the role of Th-17 cytokines is confirmed, it might provide a new option in controlling this refractory subtype of asthma.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783330038974\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783330038974","offer_id":39422652776541,"sku":"9783330038974","price":49.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/80938026-6da2-467e-9649-ddfe44aa7e71.jpg?v=1769664527","url":"https:\/\/shop.autorenwelt.de\/products\/expression-of-th17-related-cytokines-il17a-and-f-in-severe-asthma-von-wisam-al-ramli","provider":"Autorenwelt Shop","version":"1.0","type":"link"}