{"product_id":"exploring-privileged-heterocyclic-scaffolds-their-scope-as-novel-anti-inflammatory-drug-candidates-von-rajeev-kharb","title":"Exploring Privileged Heterocyclic Scaffolds:","description":"\u003cp\u003eInflammation is characterized by redness, heat, swelling, pain and sometimes loss of function of tissues. Cyclooxygenases (COXs) are mainly responsible for inflammation. Constitutive COX-1 is responsible for providing cytoprotection in gastrointestinal (GI) tract whereas inducible COX-2 facilitates inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to treat the signs and symptoms of inflammation. Traditional non-steroidal anti-inflammatory drugs (NSAIDs) such as Aspirin, Diclofenac, Flurbiprofen and Ibuprofen act via the inhibition of the COX-1 isoenzyme or the combined inhibition of COX-1 and COX-2 isoenzymes. However they show greater selectivity for COX-1 than COX-2 as well as produce serious side effect like hepatic toxicity. Therefore, it is urgently required to identify new targets that are essential for the design and development of novel anti-inflammatory agents as an alternative to NSAIDs. The relevant information provided in this manuscript can be found useful for drug design of novel anti-inflammatory agents having greater safety, selectivity and potency as well as lesser side effects.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786139900893\"\u003e\u003ch3\u003eTheir Scope as Novel Anti-Inflammatory Drug Candidates\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9786139900893","offer_id":39464818999389,"sku":"9786139900893","price":39.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/61d3418a-7925-4c16-ab0a-822b5e6e9979.jpg?v=1769842635","url":"https:\/\/shop.autorenwelt.de\/products\/exploring-privileged-heterocyclic-scaffolds-their-scope-as-novel-anti-inflammatory-drug-candidates-von-rajeev-kharb","provider":"Autorenwelt Shop","version":"1.0","type":"link"}