{"product_id":"estrogen-on-impaired-cardiac-glucose-uptake-in-cardiac-hypertrophy-von-vijayakumar-govindaraj","title":"Estrogen on impaired cardiac glucose uptake in cardiac hypertrophy","description":"\u003cp\u003eThe aim of the study was to determine whether estrogen improves the impaired cardiac glucose uptake in cardiac hypertrophy which could provide a mechanism to explain the prevention of cardiac hypertrophy by estrogen using spontaneously hypertensive rats (SHR). To examine this ovariectomized (OVX) and ovariectomized estradiol-implanted (OVX-E2) SHR rats were analyzed. At the end of the treatment the degree of cardiac hypertrohy, serum hormone levels, cardiac glucose uptake by FDG-PET and GLUT4 localization and expression, and cardiac hexokinase activity were analyzed. Results revealed that estrogen substitution inhibits uterine atrophy and cardiac hypertrophy in OVX+E2 group compared to OVX. PET analysis showed a significant increase in myocardial glucose uptake in OVX+E2 compared to OVX group. Confocal microscopy and western blotting demonstrated higher GLUT4 translocation on plasma membrane in E2 treated rat heart. Micro-array gene expression analysis showed differentially expressed genes that are involved in the mTOR signaling pathway which is known to be activated during cardiac hypertrophy.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783639714678\"\u003e\u003ch3\u003eImprovement of impaired cardiac glucose uptake: A mechanism for estrogen attenuated cardiac hypertrophy in SHR rats\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783639714678","offer_id":39467094343773,"sku":"9783639714678","price":36.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/65dfc2d3-cfa6-4e4b-aec8-32d654dd1299.jpg?v=1773727717","url":"https:\/\/shop.autorenwelt.de\/products\/estrogen-on-impaired-cardiac-glucose-uptake-in-cardiac-hypertrophy-von-vijayakumar-govindaraj","provider":"Autorenwelt Shop","version":"1.0","type":"link"}