{"product_id":"eosinophil-mediators-their-toxicity-on-breast-cancer-cells-von-michelle-law","title":"Eosinophil mediators \u0026 their toxicity on Breast Cancer cells","description":"\u003cp\u003eEosinophils are known for their role as anti-helminthic agents \u0026amp; as inflammatory effectors in allergic hypersensitivity \u0026amp;bronchial asthma. Their granules contain extremely cytotoxic proteins which are responsible for damage to the normal epithelia, \u0026amp; contribute to allergic responses \u0026amp; the onset of asthma. Preliminary observations had shown tumor cell growth was inhibited by a crude eosinophil protein extract \u0026amp; partially inhibited by IL-4 \u0026amp; TNF-¿; also produced by eosinophils. Characterization of the protein isolated from the granules confirmed its identity as that of the eosinophil major basic protein as demonstrated by silver stain \u0026amp; western blot. The growth of both cancer cell lines was significantly inhibited by the protein isolate alone \u0026amp; in combination with select inflammatory \u0026amp; non-inflammatory cytokines. Additional results showed that the combination of protein isolate and selected cytokines differentially down-regulated the expression of oncogenes in the cell lines. The results demonstrate the functional potency of this eosinophil granular mediator in inhibiting in vitro tumor cell growth \u0026amp; suggest an effector role for this cell in the host response against breast cancer.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659936524\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659936524","offer_id":39450617413725,"sku":"9783659936524","price":49.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/88b466d9-9527-480d-81c9-c7e4afcbc947.jpg?v=1776232597","url":"https:\/\/shop.autorenwelt.de\/products\/eosinophil-mediators-their-toxicity-on-breast-cancer-cells-von-michelle-law","provider":"Autorenwelt Shop","version":"1.0","type":"link"}