{"product_id":"enhancement-of-solubility-and-dissolution-rate-using-modified-guar-gum-enhancement-of-bioavailability-by-using-natural-polymer-von-vipul-jambukiya-ramesh-parmar-n-r-sheth","title":"Enhancement of Solubility and Dissolution Rate Using Modified Guar Gum","description":"\u003cp\u003ePresent study examines the effect of Guar gum (GG) and Modified guar gum (MGG) on the oral bioavailability of a poorly water-soluble drug, Ibuprofen (IBU). Modified guar gum (MGG) was prepared using heat treatment (125-130oC for 2 to 3 hours) method. It was characterized for viscosity, swelling index and water retention capacity. The physical and co-grinding mixtures of IBU with GG and MGG were prepared in 1:9 drug to gum ratio. The physical and co-grinding mixtures were characterized by DSC, FT-IR. The studies confirmed that there was no interaction between drug and carrier. Prepared mixtures were evaluated for solubility study and in vitro dissolution studies. The rank order of solubility was IBU\u003cgrounded ibu mixture co-grinding of and mgg. the bioavailability study ibu:gg ibu:mgg were done using male sprague-dawley rats. drug serum concentration was estimated hplc method. cmax value ibuprofen found in case higher as compared to pure mixtures. about improvement oral resulted with mixture.\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659337536\"\u003e\u003ch3\u003eEnhancement of Bioavailability by Using Natural Polymer\u003c\/h3\u003e\u003c\/div\u003e\u003c\/grounded\u003e\u003c\/p\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659337536","offer_id":39433874636893,"sku":"9783659337536","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/f93d9a64-5383-4bf5-9c30-80b67d4f0734.jpg?v=1769665165","url":"https:\/\/shop.autorenwelt.de\/products\/enhancement-of-solubility-and-dissolution-rate-using-modified-guar-gum-enhancement-of-bioavailability-by-using-natural-polymer-von-vipul-jambukiya-ramesh-parmar-n-r-sheth","provider":"Autorenwelt Shop","version":"1.0","type":"link"}