{"product_id":"electrochemical-impedimetric-immunosensors-for-cardiac-pathology-von-md-morsaline-billah","title":"Electrochemical impedimetric immunosensors for cardiac pathology","description":"\u003cp\u003eImmunosensors rely on antibody-antigen binding with  a range of possible detection methodologies. In this  study, electrochemical impedance spectroscopy (EIS)  was used to monitor the sensor surface assembly and  recognition of three different analytes of cardiac  pathology, myoglobin, cardiac troponin I (cTnI) and  soluble lectin-like oxidized LDL receptor-1 (sLOX- 1). Myoglobin is rapidly released into the  circulatory system after an acute myocardial  infarction (AMI) and rapidly rising levels make it  the first biochemical marker of myocardial damage,  whereas, cTnI is more persistence and specific  making a diagnosis more reliable. Circulating levels  of sLOX-1 serve as a marker for plaque instability  or rupture before an AMI becomes apparent and  facilitates early diagnosis of acute coronary  syndrome (ACS). The immunosensors were able to  detect a clinically relevant range of analyte  concentrations. Quartz crystal microbalance  and atomic force microscopy studies were carried out  to elucidate binding characteristics and surface  nanotopography. Additionally, radio-labelling  studies  were carried out to determine the apparent  binding affinity (kd) of the immunosensors.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783844315721\"\u003e\u003ch3\u003eA study to develop electrochemical impedimetric immunosensors to detect biomarkers of cardiac  pathology\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783844315721","offer_id":39495975632989,"sku":"9783844315721","price":79.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/6ae8e1fa-d2ee-436c-bb65-e8cb9c4a9469.jpg?v=1758952648","url":"https:\/\/shop.autorenwelt.de\/products\/electrochemical-impedimetric-immunosensors-for-cardiac-pathology-von-md-morsaline-billah","provider":"Autorenwelt Shop","version":"1.0","type":"link"}