{"product_id":"effects-of-punica-granatum-and-or-sitagliptin-on-diabetic-nephropathy-in-male-rats-von-hanan-mohamed","title":"Effects of Punica granatum and\/ or Sitagliptin on diabetic nephropathy in male rats","description":"\u003cp\u003eType 2 diabetes mellitus (T2DM) represents about 90% of diabetic cases. Diabetic nephropathy is one of the most serious complications of diabetes. Sitagliptin has an important role in enhancement of the Glucagon-like peptide receptor (GLP-1R) which present in the kidneys, so it may have a role in enhancement of the kidney function in T2DM. Also, Punica granatum peels extract (PGPE) is a herb which has an anti-hyperglycemic and antioxidant activities. This study was designed to investigate the role of PGPE and\/or sitagliptin on renal functions in induced diabetes. Results of the present work showed that administration of streptozotocin-nicotinamide induced oxidative stress, inflammation and hyperglycemia which play a significant role in diabetes and its complications. The improvement is due to the antidiabetic, anti-inflammatory, and antioxidative actions of sitagliptin and Punica granatum peels. The combination of Punica granatum and sitagliptin compared to monotherapy have better renoprotective effects in diabetic rats.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786203041064\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9786203041064","offer_id":39465335586909,"sku":"9786203041064","price":76.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/560ab20d-d14e-450d-8722-e4cbe927a743.jpg?v=1775711701","url":"https:\/\/shop.autorenwelt.de\/products\/effects-of-punica-granatum-and-or-sitagliptin-on-diabetic-nephropathy-in-male-rats-von-hanan-mohamed","provider":"Autorenwelt Shop","version":"1.0","type":"link"}