{"product_id":"dynamics-of-permselectivity-of-the-glomerular-capillary-wall-von-ehab-mohamed","title":"Dynamics of Permselectivity of the Glomerular Capillary Wall","description":"\u003cp\u003eThe structure, function, and composition of the  basement membrane of glomerular capillaries of the  mammalian kidney have been extensively studied, in  light of the membrane''s frequent involvement in  renal diseases. A novel mathematical  model, based on the Fiber Matrix Theory, was  developed to describe the dynamics of  permselectivity of the glomerular capillary barrier  using mainly its hemodynamic and morphometric  variables. The glomerular basement membrane was  represented as a homogeneous 3D meshwork of fibers  of uniform length (L¿), radius (R¿), and packing  density (N¿v) and characterized by a local Darcy  permeability. The model was appropriate for  simulating in vivo fractional clearance data of  neutral test macromolecules from an experimental rat  model. We believe that the L¿ and R¿ best-fit  numerical values, characterizing a glomerular  basement membrane geometrical arrangement, may  represent diagnostic measures for renal function in  health and disease. That is, these parameters may  signify new insights for the diagnosis of some human  nephropathies and possibly may explain the  beneficial effects and\/or sites of action of some  pharmacological modifiers.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783843365390\"\u003e\u003ch3\u003eMathematical Modeling of the Size-Selective Function of Renal Glomerular Capillaries in Healthy and Altered Conditions\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783843365390","offer_id":54103014048069,"sku":"9783843365390","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/cc3dbfe4-398f-4102-a409-40404286f511.jpg?v=1741418142","url":"https:\/\/shop.autorenwelt.de\/products\/dynamics-of-permselectivity-of-the-glomerular-capillary-wall-von-ehab-mohamed","provider":"Autorenwelt Shop","version":"1.0","type":"link"}