{"product_id":"dual-role-of-geminin-protein-during-human-cell-cycle-von-andrea-ballabeni","title":"Dual Role of Geminin Protein During Human Cell Cycle","description":"\u003cp\u003eDNA replication initiates in eukaryotes from thousands of replication  origins that progressively fire during S phase of the cell cycle. To  accomplish this, each origin needs first to be licensed through the  formation of a pre-Replicative Complex containing the Cdt1 protein.  Geminin protein was previously shown to inhibit Cdt1 activity and  prevent chromatin licensing before mitotic exit. In this book I  specifically investigate the role of Geminin during the entire cell  cycle of human cells and I show that Geminin has a dual role. In  addition to its role in prevention of unscheduled licensing, Geminin  protects Cdt1 from degradation and ensures its accumulation during  G2-phase and mitosis. Thus, Geminin is both a positive and a  negative regulator of Cdt1 in human cells and in this way it  safeguards the integrity of the genome by ensuring that each  portion of the DNA is duplicated on time and only once. The  previously unidentified positive role in DNA replication and cell cycle  progression is consistent with the evidence that Geminin is  abundant in hyper-proliferating cells and cancer.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838308845\"\u003e\u003ch3\u003eHow the protein Geminin safeguards the human genome\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838308845","offer_id":39497036726365,"sku":"9783838308845","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/3cba2ddf-b72a-4cb7-8268-6a831a4b9709.jpg?v=1773125616","url":"https:\/\/shop.autorenwelt.de\/products\/dual-role-of-geminin-protein-during-human-cell-cycle-von-andrea-ballabeni","provider":"Autorenwelt Shop","version":"1.0","type":"link"}