{"product_id":"drosophila-melanogaster-an-model-system-for-toxicity-studies-von-deepak-balaji-thimiri-govindaraj","title":"Drosophila melanogaster an model system for toxicity studies","description":"\u003cp\u003eThe purpose of the study was to examine the currently used two organophosphate pesticides Dichlorvos and Chlorpyrifos on Drosophila melanogaster, a  non-target organism. The toxic effect was examined by the three major endpoints of oxidative stress. The fly mortality observed at  the  highest  concentration of  Dichlorvos  indicates severity of  the  pesticide action on  the organism. Such a drastic effect may be due the inhibitory effect of key neurotransmitter enzyme acetylcholinesterase resulting into  irreparable damage to the vital cellular activities as reported earlier. The induction of key anti-oxidant enzymes Catalase and Superoxide dismutase and LPO activity  indicates oxidative stress  caused  by  the  organophosphate  pesticides in  the  exposed organism. Such a stress may arise due to generation of free radicals in the pesticide exposed flies. Another observation was that pesticide induced oxidative stress was  maximum in the old flies supporting the earlier reports that aging causes more free radical generation and less quenching of free radicals. This study further emphasizes the utility of using fruitfly as a model for studying basic biological process in eukaryotes\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783845411477\"\u003e\u003ch3\u003eBiochemical studies on anti-oxidative enzyme  activity in Drosophila melanogaster against pesticide exposure\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783845411477","offer_id":39497199222877,"sku":"9783845411477","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/20015c11-31a2-4568-bdb5-aff1ffd93fc9.jpg?v=1773296625","url":"https:\/\/shop.autorenwelt.de\/products\/drosophila-melanogaster-an-model-system-for-toxicity-studies-von-deepak-balaji-thimiri-govindaraj","provider":"Autorenwelt Shop","version":"1.0","type":"link"}