{"product_id":"dot1l-in-hematopoiesis-and-leukemia-von-stephanie-jo","title":"Dot1l in hematopoiesis and leukemia","description":"\u003cp\u003eDisruptor of telomeric silencing 1-like (Dot1l) is a  histone 3 lysine 79 methyltransferase.   Constitutive  Dot1l knockout mice studies show that Dot1l is  essential for prenatal development and hematopoiesis.   Dot1l also interacts with fusion partners of Mixed  Lineage Leukemia (MLL) gene, which is commonly  translocated in human leukemia.  However, the  requirement of Dot1l in postnatal hematopoiesis and  leukemogenesis of MLL translocation proteins have not  been conclusively shown.  With conditional Dot1l  knockout mouse model, we examined the consequences of  Dot1l loss in postnatal hematopoiesis and MLL  translocation leukemia.  Deletion of Dot1l led to  failure of hematopoietic homeostasis, and Dot1l- deficient cells minimally reconstituted recipient  bone marrow. In addition, MLL-AF9 cells required  Dot1l for oncogenic transformation, while cells with  other leukemic oncogenes such as Hoxa9\/Meis1 and E2A- HLF did not.  Furthermore, loss of Dot1l affected  histone modification at select loci instead of  leading to global changes.  These findings illustrate  a crucial role of Dot1l in normal hematopoiesis,  leukemogenesis of specific oncogenes, and histone  cross-talk.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783844383706\"\u003e\u003ch3\u003eThe role of Dot1l in normal hematopoiesis and MLL translocation leukemia\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783844383706","offer_id":39470087635037,"sku":"9783844383706","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/0cab244d-0774-4d06-9cf5-c5a27b69ce0b.jpg?v=1757656159","url":"https:\/\/shop.autorenwelt.de\/products\/dot1l-in-hematopoiesis-and-leukemia-von-stephanie-jo","provider":"Autorenwelt Shop","version":"1.0","type":"link"}