{"product_id":"dostizheniq-w-oblasti-himicheskih-modifikacij-dnk-i-ih-rol-w-terapii-von-sarika-saxena","title":"Dostizheniq w oblasti himicheskih modifikacij DNK i ih rol' w terapii","description":"\u003cp\u003eV ätoj knige rasskazywaetsq o strukturah DNK bolee wysokogo porqdka, w osnownom ob i-motifah i G-kwadruplexah. Posledowatel'nosti, sposobnye obrazowywat' G-kwadruplexy i i-motify, raspolagaütsq po wsemu genomu, glawnym obrazom w promotorah onkogenow i telomernoj DNK cheloweka, i obrazuüt wnutrimolekulqrnye tetraplexnye struktury wo wremq regulqcii äxpressii onkogenow na urowne transkripcii. Dwa wazhnyh äpigeneticheskih markera w genome cheloweka, 5-metilcitozin (mC) i 5-gidroximetilcitozin (hmC), wowlecheny w processy regulqcii genow. V ätoj knige takzhe rassmatriwaütsq razlichnye aspekty bogatoj guaninom G-kwadruplexnoj struktury DNK, kotoraq obrazuetsq w promotornoj oblasti gena-regulqtora pod nazwaniem c-myc. Razlichnye ligandy i belki pomogaüt stabilizirowat'\/destabilizirowat' strukturu G-kwadruplexa, prisutstwuüschuü w regulqtornom gene, no pri rake nablüdaetsq mutirowawshaq wersiq c-myc, chto priwodit k izmeneniü funkcij i äxpressii transkripcionnogo belka, weduschego k nereguliruemomu rostu i rasprostraneniü kletok. Takim obrazom, G-kwadruplexy pomogaüt w regulqcii aktiwnosti fermenta telomerazy i mogut prolozhit' put' k sozdaniü protiworakowyh preparatow, kotorye neobhodimy w nastoqschee wremq.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786204526003\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786204526003","offer_id":39887514173533,"sku":"9786204526003","price":19.8,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/a2df966e-fe45-406d-9d34-fbb5e72b71d8.jpg?v=1758003209","url":"https:\/\/shop.autorenwelt.de\/products\/dostizheniq-w-oblasti-himicheskih-modifikacij-dnk-i-ih-rol-w-terapii-von-sarika-saxena","provider":"Autorenwelt Shop","version":"1.0","type":"link"}