{"product_id":"dose-painting-imrt-using-biological-parameters-von-yusung-kim-und-wolfgang-a-tome","title":"Dose Painting IMRT Using Biological Parameters","description":"\u003cp\u003eCurrently, there is great interest in incorporating biological information into intensity-modulated radiotherapy (IMRT) treatment planning with the aim of selectively boosting high-risk tumor subvolumes ¿ a concept that has also been called ¿dose painting¿. However, conventional IMRT optimization utilizes dose-volume based objective functions, which have inherent limitations such as pursuing homogeneous dose distributions and assuming linear-dose-response curves. In this book we present a dose painting IMRT optimization-framework in which nonlinear biological objective functions are utilized. Prostate cancer has been used as a model system to explore its feasibility. The impact of functional imaging accuracy such as sensitivity and specificity on dose painting IMRT is subsequently presented. A comparison study between dose painting IMRT strategies and uniform-boosting IMRT strategies yielding the same EUD to the overall PTV is also presented. A novel dose painting IMRT strategy using biological parameters is proposed and promises increased expected local control for locoregionally advanced tumors with equivalent or better normal tissue sparing.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783639702729\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783639702729","offer_id":39467293147229,"sku":"9783639702729","price":51.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/b0197acc-0fe3-45a0-9cb8-603f691a6eb1.jpg?v=1769493574","url":"https:\/\/shop.autorenwelt.de\/products\/dose-painting-imrt-using-biological-parameters-von-yusung-kim-und-wolfgang-a-tome","provider":"Autorenwelt Shop","version":"1.0","type":"link"}