{"product_id":"dna-content-analysis-and-invitro-cytotoxicity-in-bladder-cancer-patients-von-saurabh-varma","title":"DNA Content Analysis and Invitro Cytotoxicity in Bladder Cancer Patients","description":"\u003cp\u003eTransitional Cell Carcinoma accounts for more than 90% of bladder cancer. DNA analysis is the second most important application of flow cytometry. DNA content of individual cells give information about their ploidy in tumours and the distribution of  cells across the cell cycle. Tumor DNA content has  been found to be of prognostic importance for  patients with many malignant tumors, such as  carcinoma of urinary bladder. In-vitro cytotoxic  studies on patients own cultured tumor tissue cells  was done  for the optimum cytotoxic combination of  chemotherapeutic drugs and immunomodulators. This  study was proposed   investigate the DNA content  evaluation and invitro monitoring of cytotoxicity  produced by various chemotherapeutic agents viz  Doxorubicin, Mitomycin C and Cisplatin on cultured  cancer cells of patients having superficial TCC,  individually as well as in combination of  immunomodulating agents BCG and interferon alpha- 2b.Out of 25 samples nine were were aneuploid,  one diploid and one tetraploid.Grade II samples  were 70%. Out of 22 samples on which cytotoxicity  test performed, 36.4% showed maximum cytotoxicity  to the combination therapy and 5 showed to BCG drug.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783843364133\"\u003e\u003ch3\u003eFlow Cytometric Evaluation of DNA Content Analysis and Therapeutic Responses (Invitro Cytotoxicity) of Transitional Cell Carcinoma Patients\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783843364133","offer_id":39497027354717,"sku":"9783843364133","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/b6aed2ae-012f-4c23-9dc8-9650f9dbcedb.jpg?v=1769667232","url":"https:\/\/shop.autorenwelt.de\/products\/dna-content-analysis-and-invitro-cytotoxicity-in-bladder-cancer-patients-von-saurabh-varma","provider":"Autorenwelt Shop","version":"1.0","type":"link"}