{"product_id":"dna-binding-aromatic-drug-molecules-von-maxim-evstigneev","title":"DNA-binding aromatic drug molecules","description":"\u003cp\u003eAromatic molecules have been widely utilized in  medicine as components of therapeutic drugs  effective against various diseases. Of utmost  importance now is the use of aromatic drugs in  combination (combinational therapy), which leads to  synergistic improvement of the chemotherapeutic  index compared to when used alone (monotherapy). In  the majority of cases the mechanisms of biological  synergy are unknown or not explained at the  cellular level. This review focuses on the  biological role of direct intermolecular  interaction of DNA-binding aromatic drug molecules,  including their self-association, hetero- association, DNA complexation and specific  molecular mechanisms operating in three-component  systems, Drug1-Drug2-DNA. The theory  of ¿interceptor-protector'' action is discussed,  providing a molecular insight into the mechanisms  of biological synergism. This monography should be  useful for anyone working in the fields of  biophysical and medicinal chemistry and dealing  with interactions of DNA-targeting drug molecules.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783843353892\"\u003e\u003ch3\u003ePhysico-chemical interactions and their biological roles\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783843353892","offer_id":39470056177757,"sku":"9783843353892","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/9ca3200e-762c-43b5-bcd7-098c55dc021f.jpg?v=1773296792","url":"https:\/\/shop.autorenwelt.de\/products\/dna-binding-aromatic-drug-molecules-von-maxim-evstigneev","provider":"Autorenwelt Shop","version":"1.0","type":"link"}