{"product_id":"dithiocarbazates-coordination-compounds-and-biological-activities-von-mohd-abdul-fatah-abdul-manan","title":"Dithiocarbazates: Coordination compounds and biological activities","description":"\u003cp\u003eSchiff bases formed from the condensation reaction  of S-benzyldithiocarbazate (SBDTC) and S- methyldithiocarbazate (SMDTC) with selected diketones  containing isatin derivatives namely isatin,5- fluroisatin,5-chloroisatin,5-bromoisatin and  methylisatin have been synthesised.Complexes of  cobalt (II), nickel (II), copper (II), zinc (II) and cadmium (II) with these Schiff bases were prepared.X-ray  crystallographic study of SB5ClISA and SB5BrISA  Schiff bases proved that the condensation reaction  between SBDTC with the isatin derivatives occur at  the carbonyl position number 3 in the isatin  ring.Crystal structure analyses of Co (II) and Ni(II)  complexes are six-coordinate with a distorted  octahedral geometry.Crystal structure of the Cu(II)  complex exhibited distorted square planar  geometry. The Schiff bases and their metal complexes  were evaluated for cytotoxic and antimicrobial  activity. Cytotoxic screening was carried out against  MCF-7 and MDA-MB-231 human breast cancer cells. Some  of the compounds were found very active with a CD50  values lower than Tamoxifen. All compounds were  found to have low or no activity against the  selected bacteria and fungal strains.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838379944\"\u003e\u003ch3\u003eSynhesis, characterisation and biological activities of Schiff Base Ligands Containing isatin and their transition metal complexes\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838379944","offer_id":39499034787933,"sku":"9783838379944","price":79.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/300c98d3-c56d-49cf-92ca-b5255010fec2.jpg?v=1769150336","url":"https:\/\/shop.autorenwelt.de\/products\/dithiocarbazates-coordination-compounds-and-biological-activities-von-mohd-abdul-fatah-abdul-manan","provider":"Autorenwelt Shop","version":"1.0","type":"link"}