{"product_id":"discrete-element-based-simulation-and-reduced-order-modeling-of-pharmaceutical-roller-compaction-von-christian-eichler-und-chritian-eichler","title":"Discrete-Element-Based Simulation and Reduced-Order Modeling of Pharmaceutical Roller Compaction","description":"In early-stage drug development, only a few grams of active ingredient are typically available, far too little for production trials on an industrial scale. Process design for dry granulation via roller compaction must therefore rely on small-scale trials and predictive models rather than extensive experiments.\nThis dissertation traces the path of the powder along the entire process chain, from roller compaction through grinding to the finished tablet. Discrete-element simulations using a cohesive contact model, supported by particle tracking and μCT measurements, show how stress, particle motion, and ribbon porosity develop between the rollers. They show that the highest stress occurs slightly before the narrowest gap, where the material moves briefly faster than the roller surface. A simulation-based fracture model then describes the granules after grinding in a two-dimensional size-porosity distribution and reproduces the bimodal particle sizes observed in experiments. Finally, a compact reduced-order model predicts tablet porosity and tensile strength directly from the process parameters. With only two machine-specific correction parameters, it proved to be accurate for two excipients with very different compaction behaviors, mannitol and MCC.\nBecause these methods require only a small number of calibration tests, they reduce the experimental workload and support early-stage process and formulation decisions when materials are in short supply.\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783689526269\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783689526269","offer_id":59877718425925,"sku":"9783689526269","price":98.4,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/73461_e314660e-9148-4e9b-996a-30e8f8bceb46.jpg?v=1792991207","url":"https:\/\/shop.autorenwelt.de\/products\/discrete-element-based-simulation-and-reduced-order-modeling-of-pharmaceutical-roller-compaction-von-christian-eichler-und-chritian-eichler","provider":"Autorenwelt Shop","version":"1.0","type":"link"}