{"product_id":"diagnosis-of-hirschsprungs-disease-von-raja-jouini-imen-helal-und-sarra-yacoub","title":"Diagnosis of Hirschsprung's disease","description":"\u003cp\u003eHirschsprung's disease (HD) is a rare congenital disorder defined by the absence of ganglion cells (GCs) in a segment of the digestive tract. Its diagnosis in Tunisia relies solely on histopathological study with hemathein-eosin. Currently, several studies are being carried out on biomarkers of MH, notably on the anti-calretinin antibody. The aim of our work was to evaluate the diagnostic performance of the anti-calretinin antibody in the context of suspected HD. This was a retrospective study including 69 patients with MH. An immunohistochemical study with anti-calretinin antibody was performed. In MPA biopsies, CGs were labeled in 2 biopsies, while interstitial nerve fibers were labeled in 3 biopsies. The sensitivity, specificity, positive predictive value and negative predictive value of the anti-calretinin antibody were 93%, 100%, 100% and 70% respectively.The use of an immunohistochemical study with anti-calretinin antibody in the absence of GC is a reasonable alternative in view of the serious therapeutic implications of HD.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786208624392\"\u003e\u003ch3\u003eStudy of the diagnostic performance of the anti-calretinin antibody.\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786208624392","offer_id":54129335140677,"sku":"9786208624392","price":60.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/3fddbe00-68e1-493a-b592-8b9c9a174f71.jpg?v=1769755062","url":"https:\/\/shop.autorenwelt.de\/products\/diagnosis-of-hirschsprungs-disease-von-raja-jouini-imen-helal-und-sarra-yacoub","provider":"Autorenwelt Shop","version":"1.0","type":"link"}