{"product_id":"development-and-characterization-of-rosiglitazone-nanoparticles-von-vandana-singh-amrendra-chaudhary-und-shamim-ahmed","title":"DEVELOPMENT AND CHARACTERIZATION OF ROSIGLITAZONE NANOPARTICLES","description":"\u003cp\u003eNanoparticles have gained much attention as a  promising drug delivery system due to their unique  properties. Rosiglitazone maleate, an antidiabetic  agent, acts as a highly selective and potent  agonist for PPAR receptors in target tissues for  insulin action. In spite of its high efficiency,  side effects limit the clinical use. To reduce the  side effects of conventional dosage form,  rosiglitazone loaded nanoparticles have been  formulated. Nanoparticles were formulated by  gelatin and chitosan via double desolvation and  ionotropic gelation technique respectively, \u0026amp;  subjected to photon correlation spectroscopy,  transmission electron microscopy \u0026amp; encapsulation  efficiency studies. These studies favorably  revealed that the mean particle diameter of  optimized formulation was 49 nm (gelatin) and 86 nm  (chitosan) with spherical morphology. The optimized  formulation demonstrated favorable in vitro  prolonged release characteristics with zero order,  diffusion and erosion mechanisms. Nanoparticles  also showed excellent stability. Hence, the  designed delivery system can be fine tuned on the  depending clinical applications.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783844393682\"\u003e\u003ch3\u003eIonotropic Gelation and Double Desolvation Technique\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783844393682","offer_id":39497152495709,"sku":"9783844393682","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/be191cdf-d46d-46d8-ac3b-d6a5a4855db9.jpg?v=1738306766","url":"https:\/\/shop.autorenwelt.de\/products\/development-and-characterization-of-rosiglitazone-nanoparticles-von-vandana-singh-amrendra-chaudhary-und-shamim-ahmed","provider":"Autorenwelt Shop","version":"1.0","type":"link"}