{"product_id":"controlled-release-formulation-of-antihypertensive-drugs-von-dheeraj-baviskar-r-b-sharma-und-d-k-jain","title":"CONTROLLED RELEASE FORMULATION OF ANTIHYPERTENSIVE DRUGS","description":"\u003cp\u003eIn present work  an attempt has been made to improve  to the therapeutic efficacy, systemic absorption of  drug and patient compliance by developing extended  release matrix tablet formulations of diltiazem HCl  (DIL) and verapamil HCL (VER). DIL and VER matrix  tablet formulations were prepared by direct  compression by using various combination of HPMC  K15M CR and Eudragit RSPO polymer. A full factorial  design was applied to systematically optimize drug  release profile. For optimization study and data  analysis software OPTI ¿ STAT was developed.  The  optimized formulations shows regression value for  Higuchi kinetics indicated the diffusion dependence  for drug release. Stability trials up to three  months displayed excellent reproducibility.  In vivo  studies were carried out on the optimized batches  and CF using new developed HPLC and LC-MS\/MS   methods A good correlation between the dissolution  profiles and bioavailability indicated a linear  relationship between in vitro ¿ in vivo data.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783844392418\"\u003e\u003ch3\u003eDesign and Optimization of Controlled Release Formulations for Calcium Channel Blockers\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783844392418","offer_id":39495946076253,"sku":"9783844392418","price":79.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/6bfecb87-b6c9-43de-9a09-c454f2498228.jpg?v=1768978790","url":"https:\/\/shop.autorenwelt.de\/products\/controlled-release-formulation-of-antihypertensive-drugs-von-dheeraj-baviskar-r-b-sharma-und-d-k-jain","provider":"Autorenwelt Shop","version":"1.0","type":"link"}