{"product_id":"comprehensive-reanalysis-of-genomic-storm-transcriptomic-data-integrating-clinical-varibles-and-utilizing-new-and-old-approaches-von-deepak-tanwar","title":"Comprehensive Reanalysis of Genomic Storm (Transcriptomic) Data, Integrating Clinical Varibles and Utilizing New and Old Approaches","description":"\u003cp\u003eBachelor Thesis from the year 2014 in the subject Computer Science - Bioinformatics, grade: 165\/200 (A+), , language: English, abstract: Aim: I sought to determine trauma-specific transcriptomic signatures for septic sub-cohorts.\u003c\/p\u003e\u003cp\u003eMethods: In retrospective large-scale data analysis, I applied (old and new methods), including lagged correlation between transcripts and clinical subtype counts (by integrating over 800 samples from trauma patients).\u003c\/p\u003e\u003cp\u003eResults: Focussing on novel pathways and correlation methods we revealed (persistently down-regulated) ribosomal genes and changed time profiles of metabolic enzyme precursors \/transcripts. Candidates associated to insulin signalling, including HK3, hinted towards ¿metabolic syndrome¿. Correlation analysis yielded robust results for LCN2 and LTF (r\u0026gt;0.9), but only moderate associations to subtype counts (e.g. top-performing r (Eosinophil, IL5RA)\u0026gt;0.6).\u003c\/p\u003e\u003cp\u003eDiscussion: Gene Centred Normalisation Reduces Ambiguity and Improves Interpretation.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783656858454\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783656858454","offer_id":39433426763869,"sku":"9783656858454","price":27.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/a63acb1f-5f61-4cd0-9a45-b8f6086ccab2.jpg?v=1778218029","url":"https:\/\/shop.autorenwelt.de\/products\/comprehensive-reanalysis-of-genomic-storm-transcriptomic-data-integrating-clinical-varibles-and-utilizing-new-and-old-approaches-von-deepak-tanwar","provider":"Autorenwelt Shop","version":"1.0","type":"link"}