{"product_id":"colon-targeted-novel-drug-delivery-systems-rheumatoid-arthritis-von-s-k-uma-devi-n-narayanan-k-jaya-raja-kumar","title":"Colon Targeted Novel Drug Delivery Systems","description":"\u003cp\u003eThe objective of the present study was directed towards developing a colon specific drug delivery system of aceclofenac, the non-steroidal anti-inflammatory drug associated with circadian rhythm of chronobiological symptoms for effective management of rheumatoid arthritis. Aceclofenac is a cox 2 selective inhibitor and has better safety than conventionalnon-steroidal anti-inflammatory drugs with respect to adverse effects on gastrointestinal and cardiovascular system. Aceclofenac is rapidly and completely absorbed after oral administration. Peak plasma concentration reaches in 1-3 h after an oral dose. The plasma elimination half life of the drug is approximately 4 h. The chronopharmacological approach for the management of rheumatoid arthritis has been well documented. Considering this factor, aceclofenac under investigation in the present study was developed as a colon targeted delivery system through tablets, pellets and microspheres. Additionally a Pulsincap drug delivery of the drug was also studied to meet the objective of circadian rhythm in rheumatoid arthritis.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659403644\"\u003e\u003ch3\u003eRheumatoid Arthritis\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659403644","offer_id":39448246976605,"sku":"9783659403644","price":74.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/0081355b-f2e1-475b-bf62-737d9046e762.jpg?v=1769147188","url":"https:\/\/shop.autorenwelt.de\/products\/colon-targeted-novel-drug-delivery-systems-rheumatoid-arthritis-von-s-k-uma-devi-n-narayanan-k-jaya-raja-kumar","provider":"Autorenwelt Shop","version":"1.0","type":"link"}