{"product_id":"clinical-concerns-of-immunogenicity-produced-by-biopharmaceuticals-von-tamilvanan-shunmugaperumal","title":"Clinical concerns of immunogenicity produced by biopharmaceuticals","description":"\u003cp\u003eFollowing the administration of biopharmaceuticals  into human body, the formation of antidrug or  neutralizing antibodies and other general immune  system effects (including allergy, anaphylaxis, or  serum sickness) are of clinical concerns regarding  therapeutic efficacy and patient safety. For  example, drug-induced neutralizing antibodies to  erythropoietin (EPO) result in pure red cell  aplasia, whereas drug-induced\/acquired anti-factor  VIII antibodies worsen the pathology associated with  hemophilia. The possible mechanism, prediction and  reduction of immunogenicity produced by  biopharmaceuticals are overviewed. This book  encompasses the clinical concerns of immunogenicity  produced by various biopharmaceuticals such as  growth hormone, insulins, granulocyte-macrophage  colony-stimulating factor, interferons,  megakaryocyte differentiation and growth factor,  EPO, factor VIII, factor IX, acid alpha-glucosidase  and glatiramer acetate including their biosimilar  versions wherever possible. With this coverage of  very interesting informations, this book is an  essential reference for researchers in  pharmaceutical industry who develop  biopharmaceutical products.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783843356008\"\u003e\u003ch3\u003eMechanism, prediction and reduction\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783843356008","offer_id":39470093959261,"sku":"9783843356008","price":49.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/f6d3f4c1-9de2-4b9f-87f3-b519be534fc3.jpg?v=1769668287","url":"https:\/\/shop.autorenwelt.de\/products\/clinical-concerns-of-immunogenicity-produced-by-biopharmaceuticals-von-tamilvanan-shunmugaperumal","provider":"Autorenwelt Shop","version":"1.0","type":"link"}