{"product_id":"classifications-and-prognosis-of-myelodysplastic-syndromes-von-wijden-el-borgi-und-rania-boughzala","title":"Classifications and prognosis of myelodysplastic syndromes","description":"\u003cp\u003eMyelodysplastic syndromes (MDS) form a heterogeneous group of clonal hemopathies that are on the increase due to an aging population. Study objective: to establish the FAB and WHO 2008 classifications, IPSS and WPSS prognostic scores of 85 MDS diagnosed at our center over a 5-year period. The mean age of patients was 63.8 years. Anemia was present in 85% of patients. Dysplasia of the 3 erythroblastic, granular and megakaryocytic lineages was found in 75%, 85% and 68% of cases respectively. Cytogenetic abnormalities were present in 33% of cases, with 5q- abnormalities predominating. Refractory anemias and refractory cytopenias with multilineage dysplasia were most frequently observed. Low- and intermediate-risk groups1 according to the IPSS and low- and high-risk groups according to the WPSS were the most represented. Median survival was significantly different between prognostic groups. Transformation to acute myeloid leukemia occurred in 32% of cases. The risk of transformation was significantly different between MDS prognostic groups.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9786206194620\"\u003e\u003ch3\u003eabout 85 cases\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9786206194620","offer_id":46848873496901,"sku":"9786206194620","price":43.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/d3060167-f346-416c-874d-212a3c5b4f0f.jpg?v=1758604038","url":"https:\/\/shop.autorenwelt.de\/products\/classifications-and-prognosis-of-myelodysplastic-syndromes-von-wijden-el-borgi-und-rania-boughzala","provider":"Autorenwelt Shop","version":"1.0","type":"link"}