{"product_id":"chromosome-rearrangement-breakpoint-hot-spots-in-humans-von-krisztina-vasarhelyi","title":"Chromosome Rearrangement Breakpoint Hot Spots in Humans","description":"\u003cp\u003eChromosomes in humans occasionally break and  an exchange, inversion or other more complex  rearrangement of the broken pieces can occur. If the  breakage causes no damage to essential gene function, and if  no overall loss of chromosome material takes place, these  rearrangements can remain undetected in healthy carriers.  Problems occur when cell division, involving rearranged  chromosomes in the germ line, leads to an unbalanced  distribution of chromosomal material in the resulting  gametes. Depending on how much chromosomal material is  involved, the imbalance can cause fertility problems to severe  birth defects in the offspring. This book describes a study  attempting to identify hot spots for breakage on human  chromosomes, in a search for clues to the origin of  constitutional chromosome rearrangements. Identifying true  hot spots is complicated by ascertainment bias which comes  about frequently due to the often severe phenotypic  manifestations of chromosome rearrangements. Through  accounting for the various sources of bias, a number of  candidates for constitutional chromosome rearrangement hot  spots are  identified.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783844334920\"\u003e\u003ch3\u003eA Statistical Study\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783844334920","offer_id":39495936409693,"sku":"9783844334920","price":59.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/83a16bb1-f13d-4a7b-b198-d1c8034e805c.jpg?v=1758781241","url":"https:\/\/shop.autorenwelt.de\/products\/chromosome-rearrangement-breakpoint-hot-spots-in-humans-von-krisztina-vasarhelyi","provider":"Autorenwelt Shop","version":"1.0","type":"link"}