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The considerable biological and medicinal activities have prompted considerable research aimed at developing synthetic routes to these ring systems.A search contains a selection of the recently reported synthetic methods for the preparation of thiadiazole derivatives and their reactions with different reagents. The intoduction part contains a selection of the recently reported synthetic methods for the preparation of thiadizole derivatives and their reactions with different reagents and their biological activities.The various possible thiadizoles are 1,2,3- thiadizole,1,2,4- thiadizole,1,2,5- thiadizole and 1,3,4- thiadizole.Then in the second part , N-(5-(cyano methyl)-1,3,4- thiadizol-2-yl)benzamide was prepared and we have investigate its reactivity towards different reagents.