{"product_id":"chaperones-as-a-novel-target-against-amyloids-in-parkinsons-disease-von-ali-chaari","title":"Chaperones as a Novel Target Against Amyloids in Parkinson's Disease","description":"\u003cp\u003eProtein misfolding and amyloid formation is an underlying pathological hallmark in a number of prevalent diseases of protein aggregation, including Parkinson¿s disease (PD), Alzheimer¿s disease and Type 2 diabetes. Most importantly, the severity of these diseases appears to correlate with the degree of the deposition of amyloid aggregates. The misfolding of ¿-synuclein, a protein involved in PD, followed by its aggregation has been shown to be highly cytotoxic and to play a key role in the death of neurons. Thus, the modulation of the aggregation process, promoting the proper folding of ¿-synuclein, may be considered as an attractive avenue for a therapeutic intervention. Indeed, molecular chaperones have been shown to assist in the maintenance of a functional proteome in vivo and to prevent protein misfolding, aggregation and amyloid formation.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659517242\"\u003e\u003ch3\u003e\u003c\/h3\u003e\u003c\/div\u003e","brand":"Libri","offers":[{"title":"Softcover - 9783659517242","offer_id":39449304629341,"sku":"9783659517242","price":39.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/f0e9a93f-609f-4973-b211-78e4ea869479.jpg?v=1773469070","url":"https:\/\/shop.autorenwelt.de\/products\/chaperones-as-a-novel-target-against-amyloids-in-parkinsons-disease-von-ali-chaari","provider":"Autorenwelt Shop","version":"1.0","type":"link"}