{"product_id":"centrosome-a-geometrical-model-von-marco-regolini","title":"Centrosome: a geometrical model","description":"\u003cp\u003eThe centrosome, the main microtubule organizing center, because of the 9-fold symmetry and the conserved stereotyped geometry of its centrioles, their peculiar (likely unique)  orthogonal configuration in S\/G2 phase, and their circumferential polarity (the triplets are different and non-equivalent) may play the role of a molecular interface, composed of two orthogonal \"9-graduated centrioles\/protractors\", that recognizes and decodes topogenic targeting sequences and translates them by connecting each one with the corresponding correctly oriented microtubule: targeted molecular complexes (polarity factors, transmembrane receptors, mRNAs) can be delivered into their expected real locations in the cell. The centrosome operates as a spherical reference system organizer, capable of mapping and wiring the cell cortex, polarizing it in detail (fine-tuned polarity) generating a univocal one-to-one correspondence between centrosomal and cortical compartments. One of the two centrioles, named mother, if reversely rotationally polarized, likely constitutes the base for bilateral symmetry.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783659520839\"\u003e\u003ch3\u003eIs the centrosome a geometric molecular interface that translates topogenic sequences into precise cell locations?\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783659520839","offer_id":39482476462173,"sku":"9783659520839","price":38.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/22ad9df9-da74-4547-9caa-03cf674faf95.jpg?v=1773381573","url":"https:\/\/shop.autorenwelt.de\/products\/centrosome-a-geometrical-model-von-marco-regolini","provider":"Autorenwelt Shop","version":"1.0","type":"link"}