{"product_id":"cellular-mechanisms-underlying-arteriolar-myogenic-tone-von-brian-spurrell","title":"Cellular Mechanisms Underlying Arteriolar Myogenic Tone","description":"\u003cp\u003eThe aim of the studies was to investigate the role  of protein tyrosine phosphorylation in myogenic  responsiveness of rat skeletal muscle arterioles.   Arterioles with myogenic tone dilated in response to  treatment with broad spectrum tyrosine kinase  inhibitors that included genistein and tyrphostin  A47 and constricted to the tyrosine  phosphatase inhibitor such as pervanadate.   Tyrosine kinase activity was found to alter vessel  diameter and modulate of arteriolar tone.   However, results indicate that acute arteriolar  myogenic constriction does not itself require  tyrosine phosphorylation. Tyrosine phosphorylation  was found to be dissociated from the myogenic  contractile response. Phosphotyrosine was found to  be elevated with increasing intraluminal pressure  and when the arterioles were rendered passive by  superfusion with Calcium deplete buffer and suggests  that the increased phosphotyrosine may be related to  increased wall tension caused by the increased  intraluminal pressure.  Phosphotyrosine signal may  be relate to growth and proliferation of smooth  muscle following a sustained rise in arteriole  transmural pressure.\u003c\/p\u003e\u003cdiv class=\"aw-variant-hidden-subtitle-div\" id=\"aw-variant-subtitle-9783838380810\"\u003e\u003ch3\u003eContribution of Tyrosine Phosphorylation\u003c\/h3\u003e\u003c\/div\u003e","brand":"Autorenwelt Shop","offers":[{"title":"Softcover - 9783838380810","offer_id":39499088167005,"sku":"9783838380810","price":68.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0940\/0622\/files\/08fb4c86-7425-4d2c-9bdf-5bae184260ca.jpg?v=1774935936","url":"https:\/\/shop.autorenwelt.de\/products\/cellular-mechanisms-underlying-arteriolar-myogenic-tone-von-brian-spurrell","provider":"Autorenwelt Shop","version":"1.0","type":"link"}